Upcoming Events: Meetings

The virtual JB Johnston Club and Karger Workshop are meetings focused on evolutionary neuroscience. This two day meeting will take place October 22-23rd. Registration for the virtual JBJC club & Karger symposium on evolutionary neuroscience is now open! There will be some great talks on "heterochrony." Details to register are here: https://www.jbjclub.org/registration.html

Also, included in the program on October 23rd is how old a chimpanzee is in human days!

Cutting across structural and transcriptomic scales translates time across the lifespan and maps frontal cortex circuitry development in humans and chimpanzees

 

Christine J. Charvet

Center for Neuroscience, Delaware State University

How the unique capacities of human cognition arose in evolution is a question of enduring interest. It is still unclear which developmental programs are responsible for the emergence of the human brain. The inability to determine corresponding ages between humans and apes has hampered progress in detecting developmental programs leading to the emergence of the human brain. I harness temporal variation in anatomical, behavioral, and transcriptional variation to determine corresponding ages from fetal to postnatal development and aging, between humans and chimpanzees. This multi-dimensional approach results in 137 corresponding time points across the lifespan, from embryonic day 44 to ~55 years of age, in humans and their equivalent ages in chimpanzees. I used these data to test whether developmental programs, such as the timeline of prefrontal cortex maturation, previously claimed to differ between humans and chimpanzees, do so once variation in developmental schedules is controlled for. I compared the maturation of frontal cortex projections from structural magnetic resonance (MR) scans and from temporal variation in the expression of genes used to track long-range projecting neurons (i.e., supragranular-enirhced genes) in chimpanzees and humans. Contrary to what has been suggested, the timetable of prefrontal cortex maturation is not unusually extended in humans. This dataset, which is the largest with which to determine corresponding ages across humans and chimpanzees, provides a rigorous approach to control for variation in developmental schedules and to identify developmental programs responsible for unique features of the human brain.  

Fall Virtual Campus visits

Cornell University:

It was a pleasure to visit Cornell University at the Evo Group seminar virtually on October 1st . It was a great opportunity to share our recent efforts to expand the translating time project. This was especially significant because the translating time project was initiated and expanded on by Dr. Barbara Finlay and her colleagues at Cornell University. Dr. Barbara Clancy also contributed susbtantially.

"Integrating neuroimaging and transcriptomics to trace the evolution of development in the human lineage"

Montreal Neurological Institute:

It was a pleasure to visit the Montreal Neurological Institute virtually on September 23rd to share recent work focused on the integration across scales of biological organization. This approach enhances the study of the neural circuits in humans. Tune in for great talks in neuroscience: https://www.mcgill.ca/neuro/events

If you are are interested in learning more about our research, you can contact us to let us know that you would be interested in scheduling a virtual talk at charvetcj@gmail.com. Visiting virtually is away actually quite easy!

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© 2020 by Charvet Laboratory For Developmental Neuroscience

Contact: charvetcj@gmail.com