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The integration across scales


More than 40 publications

Diffusion MR tractography identifies pathways in the brain as shown here for a human brain. The integration of diffusion MR imaging with transcriptional data enhances the utility of diffusion MR imaging. This work was on the cover of Developmental Dynamics in 2020. 

Our paper is out in PNAS Nexus!

Screenshot 2023-07-27 at 10.25.00 PM copy.jpg

We translate time across the lifespan of humans and great apes


Charvet CJ, Ofori K, Falcone C, Rigby Dames BA. 2023. Transcription, structure, and organoids translate time across the lifespan of humans and great apes. PNAS Nexus. In Press.

Cottam NC, Bamfo T, Harrington MA, Charvet CJ, Hekmatyar K, Tulin N, Sun J. 2023. Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy. Brain Pathol. e13162.

de Sousa AA, Rigby Dames BA, Graff E, Mohamedelhassan R, Vassilopoulos T, Charvet CJ. 2023. Going beyond established model systems of Alzheimer’s disease: companion animals provide novel insights into the neurobiology of aging. Communications Biology. 6:655.

de Sousa AA, Calvey T,  Beaudet A, Bardo A, Benoit J, Charvet CJ, Dehay C, Gómez-Robles A , Gunz P, Heuer K, van den Heuvel MP,  Hurst S, Lauters P, Salagnon M, Sherwood CC, Ströckens F, Tawane M, Todorov OS, Toro R, Wei Y. From fossils to mind. Communications Biology. 6:636.

Rigby-Dames BA, Kilili  H, Charvet CJ, Díaz-Barba K, Michael J. Proulx, de Sousa AA, 

Urrutia AO. 2023. Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases. Progress in Brain Research. 275:165-215.

Charvet CJ. 2023. Mapping human brain pathways: challenges and opportunities in the integration of scales. Brain, Behavior and Evolution. In Press.

Charvet CJ, Ofori K, Baucum C, Sun J, Modrell M, Hekmatyar K, Edlow BL, van der Kouwe, A. 2022. Tracing cortical circuits in humans and non-human primates from high resolution tractography, transcriptomic, and temporal dimensions. Journal of Neuroscience. 4:3749-67.

Ding, Q, Edwards, MM, Hulke ML, Bracci AN, Hu Y, Tong Y, Zhu X, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clarke AG, Koren A. 2021. The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells. Nature Communications. 12:6746.

Charvet CJ. 2021. Cutting across structural and transcriptomic scales translates time across the lifespan in humans and chimpanzees. Proceedings of the Royal Society B. 288: 20202987.

Bonfanti L, Charvet CJ. 2021. Brain plasticity in humans and model systems.: advances, challenges, and future directions. International Journal of Molecular Science. 22:9358.

Hendy JP, Takahashi E, van der Kouwe AJ, Charvet CJ. 2020. Brain wiring and supragranular-enriched genes linked to protracted human frontal cortex development. Cerebral Cortex. 30:54-66.

Charvet CJ. 2020. Closing the gap from transcription to the structural connectome enhances the study of connections in the human brain. Developmental Dynamics. 249: 47-61.

Charvet CJ, Das A, Song JW, Tindal-Burgess DJ, Kabaria P, Dai G, Kane T, Takahashi E. 2020. High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry. Cerebral Cortex. 30: 1447-1464.

Charvet CJ, Palani A, Kabaria P, Takahashi E. 2019. Evolution of brain connections: integrating diffusion MR tractography with gene expression highlights increased cortico-cortical projections in primates. Cerebral Cortex. 17:5150-5165.

Vasung L*, Charvet CJ*, Shiohama T, Gagoski B, Levman J, Takahashi E. 2019. Ex vivo fetal brain MRI: recent advances, challenges, and future directions. Neuroimage. 195:23-37. * These authors contributed equally.

Charvet CJ, Finlay BL. 2018. Comparing Adult Hippocampal Neurogenesis Across Species: Translating Time to Predict the Tempo in Humans. Frontiers in Neuroscience. 12:706.

Charvet CJ, Šimić G, Kostović I, Kovačević V, Vukšić M, Babić LB, Takahashi E, Sherwood CC, Wolfe MD, Finlay BL. 2017. Coevolution in the timing of GABAergic and pyramidal neuron maturation in primates. Proceedings of the Royal Society Biological Sciences. 284:pii: 20171169.

Charvet CJ, Hof PR, Raghanti MA, Van Der Kouwe AJ, Sherwood CC, Takahashi E. 2017. Combining diffusion magnetic resonance tractography with stereology highlights increased cross-cortical integration in primates. Journal of Comparative Neurology. 525:1075 1093.

Charvet CJ, Reep RL, Finlay BL. 2016. Evolution of cytoarchitectural landscapes in the mammalian isocortex: sirenians (Trichechus Manatus) in comparison with other mammals. Journal of Comparative Neurology. 524(4):772-82.

Charvet CJ, Cahalane DJ, Finlay BL. 2015. Systematic, cross-cortex variation in neuron numbers in rodents and primates. Cerebral Cortex. 25:147-60.  

Cahalane DJ, Charvet CJ, Finlay BL. 2014. Modeling local and cross-species neuron number variations in the cerebral cortex as arising from a common mechanism. Proceedings of the National Academy of Sciences USA. 111:17642-7.

Charvet CJ, Finlay BL. 2014. Evo-devo and the primate isocortex: the central organizing role of intrinsic gradients of neurogenesis. Brain Behavior and Evolution. 84:81-92.

Finlay BL, Charvet CJ, Bastille I, Cheung DT, Chalfin BP, Muniz JA, Silveira LC. 2014.  Scaling the primate lateral geniculate nucleus: niche and neurodevelopment in the regulation of magnocellular and parvocellular cell number and nucleus volume. Journal of Comparative Neurology. 522:1839-57.

Workman AD, Charvet CJ, Clancy B, Darlington RB, Finlay BL. 2013. Modeling transformations of neurodevelopmental sequences across mammalian species. Journal of Neuroscience. 33:7368-83.

Charvet CJ, Darlington RB, Finlay BL. 2013. Variation in human brains may facilitate evolutionary change toward a limited range of phenotypes. Bran Behavior and Evolution. 81:74-85. 

         Commentary in: Vallender EJ. 2013. How brains are built: genetics and evolution. Brain Behavior and Evolution. 81:71-3.

Cahalane DJ, Charvet CJ, Finlay BL. 2012. Systematic, balancing gradients in neuron density and number across the primate isocortex. Frontiers in Neuroanatomy. 6:28.

Charvet CJ, Finlay BL. 2012. Embracing covariation in brain evolution: large brains, extended development and flexible primate social systems. Progress in Brain Research. 195:71-87.

McGowan LD, Alaama RA, Freise AC, Huang JC, Charvet CJ, Striedter GF. 2012. Expansion, folding, and abnormal lamination of the chick optic tectum after intraventricular injections of FGF2. Proceedings of the National Academy of Sciences USA. 109 Suppl 1:10640-6.

Charvet CJ, Striedter GF, Finlay BL. 2011. Evo-devo and brain scaling: candidate developmental mechanisms for variation and constancy in vertebrate brain evolution. Brain Behavior and Evolution. 78:248-57.

Charvet CJ, Striedter GF. 2011. Developmental modes and developmental mechanisms can channel brain evolution. Frontiers in Neuroanatomy. 5:4.

Charvet CJ, Striedter GF. 2011. Causes and consequences of expanded subventricular zones. European Journal of Neuroscience. 34:988-93.

Charvet CJ. 2010. A reduced progenitor pool population accounts for the rudimentary appearance of the septum, medial pallium and dorsal pallium in birds. Brain Behavior and Evolution. 76:289-300.

Charvet CJ, Striedter GF. 2010. Bigger brains cycle faster before neurogenesis begins: a comparison of brain development between chickens and bobwhite quail. Proceedings of the Royal Society Biological Sciences. 277:3469-75.

Charvet CJ, Sandoval AL, Striedter GF. 2010. Phylogenetic origins of early alterations in brain region proportions. Brain, Behavior and Evolution. 75:104-10.

Charvet CJ, Striedter GF. 2009. Developmental basis for telencephalon expansion in waterfowl: enlargement prior to neurogenesis. Proceedings of the Royal Society Biological Sciences. 276:3421-27.

Charvet CJ, Owerkowicz T, Striedter GF. 2009. Phylogeny of the telencephalic subventricular zone in sauropsids: evidence for the sequential evolution of pallial and subpallial subventricular zones. Brain Behavior and Evolution. 73:285-294.

Charvet CJ, Striedter GF. 2009. Developmental origins of mosaic brain evolution: morphometric analysis of the developing zebra finch brain. Journal of Comparative Neurology. 514:203-213.

Striedter GF, Charvet CJ. 2009. Telencephalon enlargement by the convergent evolution of expanded subventricular zones. Biology Letters. 5:134-137.

Charvet CJ, Striedter GF. 2008. Developmental species differences in brain cell cycle rates in the northern bobwhite quail (Colinus virginianus) and parakeets (Melopsittacus undulatus): implications for mosaic brain evolution. Brain Behavior and Evolution. 72:295-306.

Charvet CJ, Striedter GF. 2008. Spatiotemporal clustering of cell death in the avian forebrain proliferative zone. International Journal of Developmental Biology. 52:345- 352.

Striedter GF, Charvet CJ. 2008. Developmental origins of species differences in telencephalon and tectum size: Morphometric comparisons between a parakeet (Melopsittacus undulatus) and a quail (Colinus virgianus). Journal of Comparative Neurology. 507:1663-1675.

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